June 4, 2026

The cramp wakes you up. The leg tightens down, and nothing else is happening until it releases.
Magnesium helps regulate muscle contraction and nerve signaling throughout the body. Many people end up eating fewer magnesium-rich foods once appetite and food variety both drop on GLP-1 — and that gap shows up as cramps, weakness, and fatigue before most people connect it to what they've stopped eating.
Low magnesium has been linked to muscle cramps and weakness because magnesium helps regulate muscle and nerve activity. GLP-1 medications do not directly drain magnesium, but reduced food intake can lower overall magnesium intake substantially.

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