June 4, 2026

The scale hasn't moved in three weeks. The medication is still working the way it should. The problem is that the body may have already adjusted to how little you're eating.
Research suggests that metabolic adaptation to caloric restriction occurs independently of appetite changes and may contribute to weight loss plateaus on GLP-1. The body becomes more efficient at using energy when intake is low, which reduces expenditure and can contribute to weight loss plateaus even when appetite is still suppressed.
Lean mass loss during weight reduction may also lower resting energy expenditure because lean mass contributes more to resting metabolic rate than fat mass. Losing muscle while losing weight is common on GLP-1 when protein intake is low. The metabolic slowdown that leads to plateaus is partly related to that.

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