June 4, 2026

The headache starts around noon. Not a migraine — just a dull pressure that wasn't there yesterday. On GLP-1, dehydration can develop gradually because many people report lower fluid intake alongside reduced appetite.
GLP-1 receptor agonists can slow gastric emptying (especially of solids) and alter fullness signaling in ways that may also affect fluid tolerance. Large fluid volumes may feel uncomfortable once gastric emptying slows — the same mechanism that reduces appetite also affects how much the stomach can comfortably hold. Many people stop drinking as much as normal without realizing it during reduced-appetite periods.

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